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NEW QUESTION: 1
Which of the following is true regarding extent of absorption of drugs?
A. Drugs which are too lipophilic cannot cross the lipid cell membrane
B. P-glycoprotein is an efflux transporter which is present in the enterocytes and it enhances the absorption of drug
C. Grape juice activates P-glycoprotein leading to substantial inhibition of absorption of drugs
D. Drugs which are too hydrophilic are not soluble enough to cross the water layer adjacent to the cell
E. After oral ingestion of drugs, the absorption of drug may be incomplete
It is not necessary that all the drugs get completely absorbed after oral administration. Most of them are incompletely absorbed. The extent of absorption varies from 5 to less than 100 % with oral ingestion of drugs.
Drugs which are too hydrophilic like atenolol are incompletely absorbed because the drug cannot cross the lipid membrane due to high hydrophilic nature of the drug. Similarly, drugs which are too lipophilic like acyclovir are not soluble enough to cross the water layer adjacent to the cell. P-glycoprotein is an efflux transporter which is present in the enterocytes and it inhibits absorption of drug. It is also known as export transporter or reverse transporter. It has many drugs as its substrate. Grape juice in fact inhibits P-glycoprotein in the intestine thereby decreasing the efflux of drug from the cells by P-glycoprotein. Thus ingestion of grape juice may lead to significantly increased absorption of the drug.
NEW QUESTION: 2
The four main types of NoSQL databases are:
NEW QUESTION: 3
You are designing a Windows Azure application that will store data in two SQL Azure databases. The application will insert data in both databases as part of a single logical operation. You need to recommend an approach for maintaining data consistency across the databases.
What should you recommend?
A. Handle errors resulting from the database calls by using compensatory logic.
B. Execute database calls on parallel threads.
C. Wrap the database calls in a single transaction scope.
D. Use Microsoft Distributed Transaction Coordinator (MSDTC).